• Home
  • Browse
    • Current Issue
    • By Issue
    • By Author
    • By Subject
    • Author Index
    • Keyword Index
  • Journal Info
    • About Journal
    • Aims and Scope
    • Editorial Board
    • Publication Ethics
    • Peer Review Process
  • Guide for Authors
  • Submit Manuscript
  • Contact Us
 
  • Login
  • Register
Home Articles List Article Information
  • Save Records
  • |
  • Printable Version
  • |
  • Recommend
  • |
  • How to cite Export to
    RIS EndNote BibTeX APA MLA Harvard Vancouver
  • |
  • Share Share
    CiteULike Mendeley Facebook Google LinkedIn Twitter
Menoufia Journal of Agricultural Biotechnology
arrow Articles in Press
arrow Current Issue
Journal Archive
Volume Volume 10 (2025)
Issue Issue 4
Issue Issue 3
Issue Issue 2
Issue Issue 1
Volume Volume 9 (2024)
Volume Volume 8 (2023)
Volume Volume 7 (2022)
Volume Volume 6 (2021)
Volume Volume 5 (2020)
Volume Volume 4 (2019)
Volume Volume 3 (2018)
Volume Volume 2 (2017)
Volume Volume 1 (2016)
Volume Volume 40 (2015)
Hussien, A., Elbeltagy,, A., Mansour, S., Fahim, S. (2025). EFFECT OF ZINC OXIDE NANOPARTICLES ON ANTIBIOTIC RESISTANCE OF STAPHYLOCOCCUS AUREUS ASSOCIATED WITH DIABETIC FOOT ULCERS. Menoufia Journal of Agricultural Biotechnology, 10(4), 47-58. doi: 10.21608/mjab.2025.368646.1027
Amin Hussien; A Elbeltagy,; S Mansour; S Fahim. "EFFECT OF ZINC OXIDE NANOPARTICLES ON ANTIBIOTIC RESISTANCE OF STAPHYLOCOCCUS AUREUS ASSOCIATED WITH DIABETIC FOOT ULCERS". Menoufia Journal of Agricultural Biotechnology, 10, 4, 2025, 47-58. doi: 10.21608/mjab.2025.368646.1027
Hussien, A., Elbeltagy,, A., Mansour, S., Fahim, S. (2025). 'EFFECT OF ZINC OXIDE NANOPARTICLES ON ANTIBIOTIC RESISTANCE OF STAPHYLOCOCCUS AUREUS ASSOCIATED WITH DIABETIC FOOT ULCERS', Menoufia Journal of Agricultural Biotechnology, 10(4), pp. 47-58. doi: 10.21608/mjab.2025.368646.1027
Hussien, A., Elbeltagy,, A., Mansour, S., Fahim, S. EFFECT OF ZINC OXIDE NANOPARTICLES ON ANTIBIOTIC RESISTANCE OF STAPHYLOCOCCUS AUREUS ASSOCIATED WITH DIABETIC FOOT ULCERS. Menoufia Journal of Agricultural Biotechnology, 2025; 10(4): 47-58. doi: 10.21608/mjab.2025.368646.1027

EFFECT OF ZINC OXIDE NANOPARTICLES ON ANTIBIOTIC RESISTANCE OF STAPHYLOCOCCUS AUREUS ASSOCIATED WITH DIABETIC FOOT ULCERS

Article 3, Volume 10, Issue 4, April 2025, Page 47-58  XML PDF (951.86 K)
Document Type: original papers
DOI: 10.21608/mjab.2025.368646.1027
View on SCiNiTO View on SCiNiTO
Authors
Amin Hussien email 1; A Elbeltagy,2; S Mansour2; S Fahim2
1Biotechnology, menofia university
2Agri. Microbiology, Botany Dept., Fac. Agri., Menoufia Univ., Egypt.
Abstract
Over the past decade, the rising prevalence of antibiotic resistance has posed a significant challenge to the effective treatment of numerous bacterial infections. Creating novel antimicrobial biomaterials, which unavoidably have expanded therapeutic possibilities in medical methods, also requires innovative nanomaterials. It prompts several attempts to develop novel metal oxide nanoparticles (NPs) to more effectively control the Multi Drug Resistant (MDR) bacteria responsible for diabetic foot ulcers. This work used the sol-gel method to produce zinc oxide nanoparticles, which were then characterized by X-ray diffraction, Fourier-transformed infrared, and transmission electron microscopy. The pure phase of non-agglomerated ZnO-NPs with diameters ranging from 30 to 50 nm and an average diameter of 40 nm was synthesized using the employed approach in conjunction with TEM analysis. The TEM examination indicates that the morphology of ZnO-NPs has developed to be nearly hexagonal. On the other hand, the infection by MDR S. aureus represented 21.3 % of the causes of staphylococcal diabetic foot ulcers. The treatment by ZnO-NPs inhibited the growth of Methicillin, heterogenous Oxacillin Resistant or Vancomycin Intermediated S. aureus (MRSA, ORSA, and VISA) phenotypes with an average MIC of 5.21 mM/ml. At the same time, they give MIC average values of 3.49, 2.6, 2.99, and 1.99 μg/ml for (OX, FOX, VA, and LN) individual antibiotics, respectively. In the same aspect, using syn-MICs of antibiotics and ZnO-NPs by (1:1) decreased values by a synergistic effect percentage of 309, 441, 299, and 316 %, respectively. This finding indicates a synergistic effect of combining ZnO-NPs and the tested antibiotics. This result suggests a synergistic interaction between ZnO-NPs and the tested antibiotics. According to the findings, ZnO-NPs are promising nano metal oxides that are useful for diabetic foot ulcer nanomedical therapy strategies.
Keywords
ZnO-nanoparticles; antibiotic-resistant bacteria; diabetic foot ulcers
Main Subjects
Agricultural Biotechnology and related articles researches
Supplementary Files
download مجلة المنوفيةللتكنولوجيا الحيوية الزراعية.pdf
Statistics
Article View: 45
PDF Download: 37
Home | Glossary | News | Aims and Scope | Sitemap
Top Top

Journal Management System. Designed by NotionWave.