EVALUATION OF THE HEPATO-PROTECTIVE EFFECT OF GINGER EXTRACTS AGAINST HYDROGEN PEROXIDE  IN ALBINO RAT

M. A, Habib; Taha, Kh. M; El-Refaey, Abeer A

doi:10.21608/mjab.2023.278460

EVALUATION OF THE HEPATO-PROTECTIVE EFFECT OF GINGER EXTRACTS AGAINST HYDROGEN PEROXIDE IN ALBINO RAT

Document Type : original papers

Authors

¹ Department of Biochemistry, Faculty of Agriculture, Menoufia University, Egypt.

² Department of Biochemistry, Faculty of Agriculture, Menoufia University, Egypt

³ Medical analysis specialist, Ministry of Health

10.21608/mjab.2023.278460

Abstract

Various oxidants deteriorate the functions of the body significantly, especially the functions of the liver, which is the main organ in most metabolic processes in the human body. Therefore, this study was designed to evaluate the effect of ethanolic and acetone extracts of ginger rhizomes (at concentrations 0.05 and .01% for each) against H₂O₂ (at a concentration of 0.05% in drinking water) in a one-month experiment. The results indicated a high content of both extracts (ethanolic and acetone) from total phenolics (654.8 and 563.3 mg/100g, respectively). The results of the fractionation of ethanolic and acetone extracts on the HPLC also showed that both extracts contained 16 compounds, the most important of which were zingerone and gingerols. The biological experiment showed that the treatment with H₂O₂ led to a significant increase in the levels of liver enzymes activities (ALT, AST and ALP) and a significant deterioration in the levels of both total protein and albumin in plasma. Whereas, treatment with the two extracts showed a significant improvement in liver functions, which supports the hypothesis of the positive effect of ethanol and acetone extracts for ginger rhizomes in combating free radicals that result from H₂O₂ and lead to the deterioration of liver functions.

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