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Draz, S., Farid, A., Hussein, K. (2021). TOXICOLOGICAL AND BIOCHEMICAL EFFECTS OF AFLATOXINS ON EXPERIMENTAL RATS. Menoufia Journal of Agricultural Biotechnology, 6(2), 23-24. doi: 10.21608/mjab.2021.161195
Sh. N. Draz; A. M. Farid; K. E. Hussein. "TOXICOLOGICAL AND BIOCHEMICAL EFFECTS OF AFLATOXINS ON EXPERIMENTAL RATS". Menoufia Journal of Agricultural Biotechnology, 6, 2, 2021, 23-24. doi: 10.21608/mjab.2021.161195
Draz, S., Farid, A., Hussein, K. (2021). 'TOXICOLOGICAL AND BIOCHEMICAL EFFECTS OF AFLATOXINS ON EXPERIMENTAL RATS', Menoufia Journal of Agricultural Biotechnology, 6(2), pp. 23-24. doi: 10.21608/mjab.2021.161195
Draz, S., Farid, A., Hussein, K. TOXICOLOGICAL AND BIOCHEMICAL EFFECTS OF AFLATOXINS ON EXPERIMENTAL RATS. Menoufia Journal of Agricultural Biotechnology, 2021; 6(2): 23-24. doi: 10.21608/mjab.2021.161195

TOXICOLOGICAL AND BIOCHEMICAL EFFECTS OF AFLATOXINS ON EXPERIMENTAL RATS

Article 1, Volume 6, Issue 2, March 2021, Page 23-24  XML PDF (346.56 K)
Document Type: original papers
DOI: 10.21608/mjab.2021.161195
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Authors
Sh. N. Draz1; A. M. Farid1; K. E. Hussein2
1Prof. of Biochemistry, Fac. of Agric., Menoufia Univ.
2Lecturer of Biochemistry, Fac. of Agric., Menoufia Univ.
Abstract
Aflatoxins (AFs) are a group of highly toxic mycotoxins mainly produced by Aspergillus flavus and Aspergillus parasiticus, which are considered natural contaminants of food and feed toxic to the liver, carcinogens and mutagenic. Therefore, reducing their toxicity in the body of the organism is a great importance. In this study, the aqueous extract of leaves was evaluated (green Tea and sage) to reduce the toxicity caused by aflatoxins. Two concentrations of aflatoxins (0.5 and 1 mg / kg of b.w) were taken per week for 42 days, which led to a deterioration of liver and kidney function and the level of lipid and glucose in the plasma of the treated rats. In the laboratory experiment, the aqueous extract of the plants used greatly improved these traits after they were taken daily in concentrations (200-400 mg / kg of b.w) for a period of 42 days. Thus, it can be concluded that green tea and sage showed protective effect against aflatoxin toxicity.
Keywords
Aflatoxins; Camellia sinensis; Salvia officinalis; Liver functions; Kidney functions; Lipid profile; Antioxidant parameters
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